简介:AbstractN-acetyl-cysteine (NAC) is an efficacious treatment for sensorineural hearing loss in animal models, such as noise-induced hearing loss (NIHL), however previous research into the effect of NAC on patients with hearing loss produced contradictory results. In this study, we investigated the effect of NAC treatment on sensorineural hearing loss. PubMed, Web of Science and Embase databases were searched in their entirety using the key words: hearing loss, NAC, N-acetylcysteine, and sensorineural hearing loss. Studies which included assessment of hearing loss with pure-tone threshold (PTA) data were selected. Eligible studies regarding the effects of NAC treatment on patients with hearing loss were collected by two independent reviewers. A total of 1197 individuals were included from seven published studies. Two studies reported data for a sudden idiopathic sensorineural hearing loss (SISNHL) group. Three studies reported data for a NIHL group. Other studies reported data for drug-induced hearing loss. The meta-analysis demonstrated that the overall effect of NAC treatment on sensorineural hearing loss was invalid. However, NAC treatment was linked with improved patient outcomes of hearing tests in cases of sudden hearing loss, but did not prevent hearing loss induced by noise or ototoxicity. However, there is a need for better-designed studies with larger samples to further prove the correlation between the effect of NAC and hearing loss.
简介:摘要:目的:建立盐酸乐卡地平原料中有机残留N,N-二甲基甲酰胺的含量测定方法。方法:采用气相色谱法测定N,N-二甲基甲酰胺的含量。结果:方法学验证结果表明N,N-二甲基甲酰胺在进样量为51.0~153.0μg/ml范围内,其进样浓度与峰面积呈良好线性,线性方程Y= 0.1418x -0.6255(r=0.9994)。在相当于标示限量量80%~120%范围内,平均回收率为95.8%,RSD为0.44%。结论:N,N-二甲基甲酰胺含的量测定方法操作简单,准确、快速,可用于盐酸乐卡地平原料中有机残留N,N-二甲基甲酰胺的含量测定。
简介:摘要:2022年是铝板带厂能否甩掉“亏损帽子”的关键一年,铝板带厂党委紧紧围绕减亏扭亏中心工作,积极发挥党建引领作用,在员工素质提升、安全意识增强、操作水平提高等方面持续发力,积极构建立体式培训模式,努力实现“两提高两促进”目标。实施以来收到较好成效,员工素质大幅提升,为该厂安全生产、减亏扭亏目标的实现奠定了坚实基础。
简介:摘要:党支部是党的基础组织。国有企业基层党支部,围绕企业生产经营开展工作,服务企业发展、凝聚职工群众、建设企业文化、创造一流业绩。本文通过对笔者所在的彬长矿业小庄矿经营党支部在党支部标准化建设方面的工作实践总结,探讨国有企业党支部建设的路径和成效。
简介:摘要:Mini LED背光应用在电视,车载显示,笔电,智能穿戴等产品的显示技术正在迅速发展。以图形化蓝宝石为衬底,采用有机金属化学气相沉积技术生长blue mini LED外延片。本文通过调整N型氮化镓层的成长速率,硅浓度,厚度的条件获得不同条件的外延片,将这些外延片制作成芯片并量测LED特性。研究N型氮化镓层不同成长条件对LED特性影响。
简介:摘要MARCH(membrane-associated RING-CH fingerprotein)家族是在21世纪初发现的一类E3泛素连接酶,有11个家族成员,在生物体内通过对底物蛋白进行泛素化修饰从而发挥多种调控作用。膜相关RING-CH蛋白2(membrane-associated RING-CH protein Ⅱ),简称MARCH2,常见的靶点有转铁蛋白受体(transferrin receptor,TfR)、突触融合蛋白6(syntaxin 6,STX-6)、CD86(B7-2)、人DLG1(discs large tumour suppressor)和囊性纤维跨膜传导调节因子(cystic fibrosis transmembrane conductance regulator,CFTR)以及β2肾上腺素能受体(β2-adrenergic receptors,β2-AR),在病毒免疫逃避、肿瘤发生及激动剂脱敏等方面发挥着作用。其主要通过泛素化修饰在哺乳动物的蛋白修饰及泛素化降解过程,发挥着举足轻重的作用,尤其是调控细胞内囊泡运输的蛋白及表面受体。但目前对MARCH2的功能研究仍有许多空白之处尚待填补。本文就MARCH2的起源、结构及功能进行阐述,为后续基础及临床研究提供一定的依据。