简介：Stressinducedtheseriousdisorderofcardiacfunctionandcardiovasculardiseases.Apoptosisisthecellularbasisinstressinducedcardiacinjury.Inourpreviousstudywefoundthatmanystressorsresultedinmitochondrialdamage.Itiscertainthatmitochondriaisimportantmediatorintriggeringapoptoticcelldeath,butthemechanism,bywhichthestressinducedmitochondrialinjuryleadstocardiomyocyteapoptosis,remainsunclear.Wedesignedthepresentstudytoinvestigatethechangesofthemitochondriaincardiomyocytesundergoingstressanditsroleininducingapoptosis.Herewereportedthatstresschangedthemembranefluidityofmitochondriaandinducedthelipidperoxidationofmitochondrialmembranein

简介：Hamstringmusclestraininjuryisoneofthemostcommoninjuriesinsportsinvolvingsprintingandkicking.Hamstringmusclestraininjuriesoccuratahighrateandhaveahighre-injuryrate,whichresultsinlossoftrainingandcompetitiontime,whichhasasignificantimpactonthequalityoflifeoftheinjuredathletes.~1Preventingandrehabilitatinghamstringmusclestraininjuryisanimportanttaskforcliniciansandscientistsinsportsmedicine.Understandingthemechanismsunderlyinghamstringinjuryiscriticalfordevelopingappropriatestrategiestopreventandrehabilitatehamstringinjuries.Understandingthegeneral

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简介：增加焊接穿入的A-TIG的机制被使用我们为不锈钢开发了的激活的流动学习。流动和焊接水池的温度领域上的流动的效果被PHOENICS软件模仿。它证明没有流动，液体流动将沿着焊接水池然后在下面的表面是外面的，导致flatter焊接水池形状。与流动，氧，从否定价值把表面紧张毕业生的温度依赖改变到积极价值，能在焊接穿入上引起重要变化。液体流动将沿着向中心然后在下面的焊接水池的表面是里面的。这个液体流动模式高效地把热转移到焊接根并且生产相对深、狭窄的焊接。这个变化是穿入增加的主要原因。而且，弧建设能引起焊接宽度变得更狭窄并且变得更深的穿入，但是这不是穿入增加的主要原因。焊接水池表面和弧侧面的液体流动上的流动的效果在焊接的常规TIG并且在由使用高速度的摄像机焊接的A-TIG被观察。液体流动行为被微集中的X光检查传播录像观察系统在实时规模设想。结果显示与更狭窄的宽度和更深的穿入导致焊接祷告的更强壮的里面的液体流动模式能显然在焊接的A-TIG的情况中被识别。流动能在焊接水池改变液体流动的方向。它与模拟结果有一个好协议。

简介：ThestereospecifichydrolysisofmandelatecanbeeffectivelycatalyzedbyhyperthermophilicacylpeptideesteraseAPE1547(Aeropyrumpernixesterase1547).APE1547usedinthisreactionshowedaremarkablestereodi-scriminationinfavourofR-mandelicacid(99%e.e.)withanenantiomericratioE>200.Theresultsofcomputersimulationareconsistentwiththeexperimentalresults.ItcanbeinferredthattheR-substrateadoptedabindingmodeproductiveofthereactionduetotheformationofthehydrogenbondattheactivesiteofAPE1547.

简介：Cavityoptomechanicsisappliedtostudythecouplingbehaviorofinteractingmoleculesinsurfaceplasmonsystemsdrivenbytwo-colorlaserbeams.Differentfromthetraditionalforce–distancemeasurement,duetoaresonantfrequencyshiftorapeaksplittingontheprobespectrum,wehaveproposedaconvenientmethodtomeasurethevanderWaalsforcestrengthandinteractionenergyvianonlinearspectroscopy.Theminimumforcevaluecanreachapproximately10-15N,whichis3to4ordersofmagnitudesmallerthanthewidelyappliedatomicforcemicroscope（AFM）.Itisalsoshownthattwoadjacentmoleculeswithsimilarchemicalstructuresandnearlyequalvibrationalfrequenciescanbeeasilydistinguishedbythesplittingofthetransparencypeak.Basedonthiscoupledoptomechanicalsystem,wealsoconceptuallydesignatunableopticalswitchbyvanderWaalsinteraction.Ourresultswillprovidenewapproachesforunderstandingthecomplexanddynamicinteractionsinmolecule–plasmonsystems.

简介：AbstractAtypical teratoid/rhabdoid tumors (AT/RTs) are lethal central nervous system tumors, which are primarily diagnosed in infants. Current treatments for AT/RTs include surgery, radiotherapy, and chemotherapy; these treatments have poor prognoses and challenging side effects. The pivotal genetic event in AT/RT pathogenesis comprises the inactivation of SMARCB1 or SMARCA4. Recent epigenetic studies have demonstrated mutual and subtype-specific epigenetic derangements that drive tumorigenesis; the exploitation of these potential targets might improve the dismal treatment outcomes of AT/RTs. This review aims to summarize the literature concerning targeted molecular therapies for pediatric AT/RTs.

简介：TherootsofPaeoniaelactifloraPall.arewidelyconsumedascrudedrugsinAsiancountriesduetotheirremarkablebeneficialhealtheffects.Thepresentresearchwasundertakentoilluminatethedynamicchangesinmetabolitesandenzymesandfacilitateselectionoftheharvestingtimewhentheherbcanprovideoptimumhealthbenefits.P.lactiflorarootswereanalyzedat12stagesofgrowthformonoterpenoidglycosides,phenols,nucleosides,nucleobases,aminoacids,andpolysaccharidesbyhigh-performanceliquidchromatographywithphotodiodearraydetector,ultra-highpressureliquidchromatographycoupledwithtandemmassspectrometry,andUVspectrophotometry.Theenzymeactivitiesofplantβ-glucosidasesandesterasesweredeterminedbyUVmethods.ThetotalcontentofmonoterpenoidglycosidesandphenolspeakedinDecember.Fornucleosidesandnucleobases,thehighestcontentappearedinApril.ThemaximumphasicaccumulationofthetotalaminoacidstookplaceinMarch,andthecontentoftotalpolysaccharidesreachedapeakvalueinSeptember.December,April,andMarchwereselectedastheappropriateharvestingtimesforproducingnaturalmedicinalorhealthfoodproducts.Plantβ-glucosidasesandesterasesshowedthehighestactivityinDecemberandMay,respectively.Whentheactivityofβ-glucosidaseincreased,esteraseactivitydecreased,whilethecontentsofoxypaeonifloraandpaeoniflorinincreased.Whenesteraseactivityincreased,thecontentsofbenzoylpaeoniflorin,paeoniflorin,andgallicaciddecreased.Inconclusion,theresultsfromthepresentstudywouldbeusefulindeterminationofthesuitabletimeforharvestingP.lactiflorarootsformedicinalpurposes.

简介：一有效器官光电(OPV)有indium-tin-oxide/CuPc/C60/Ag结构的房间被改变器官的层的电影厚度调查了。高开电路的电压(V0.5V的OC)，电线走火电流密度(J5.81mA/cm2的SC)，和高度驱动变换效率(η1.2%的p)在最佳电影厚度被完成。结果证明材料厚度是到房间优化的一个重要因素，特别为最大化象减少房间电阻一样的吸收率。当堵住10nm的层的BCP激子被介绍，试验性的结果也显示力量变换效率从1.2%～1.54%增加。

简介：TheexpansioncoefficientC^D｜L｜ofCoulombpotential1/jtofmolecularsystemsinhypersphericalharmonicsisderivedindetail,andtheexplicitexpressionisgiven.

简介：蛋白质符合构造上的水的影响被在不同的水系统模仿模型蛋白质溶解酵素的分子的动力学调查。有有六戒指的水的水模型和溶解酵素水簇系统建模的TIP3P的溶解酵素水系统被评估。另外，在溶解酵素附近的溶剂的光线的分发功能是计算的。在溶解酵素附近的水分子的分发类似于水簇的，这被发现。二面的角度的分析和溶解酵素的二硫化物契约证明溶解酵素的符合构造严重地在溶解酵素水系统与那相比在溶解酵素水簇系统被损坏。这差别能被归因于在溶解酵素和水簇之间的分子间的氢契约的更大的数字的形成。是与分析一致水簇能在溶解酵素的热变性作用的过程改变变性作用的度。

简介：Thepapershortlyreviewsthebasicdirectapproachesappliedinsearchingforviablesolutionstosolarfuelproduction.Thesearegenerallydistinguishedinmolecularandsemiconductor(non-molecular)systems,however,hybridstrategies,proposedrecently,havealsobeenincluded.Themostpromisingeffortsareconsidered,highlightingkeyaspectsandemergingcriticalissues.Specialattentionispaidtoaspectssuchaselectrodearchitecture,devicedesign,andmaindifferencesinthescientificvisionandchallengestodirectlyproducesolarfuels.Thisoverviewcouldbeusefultoorientatethereadersinthewidepanoramaofresearchactivitiesconcerningwatersplitting,naturalandartificialphotosynthesis,andsolarfuelproductionthroughtheidentificationofcommonaspects,specialtiesandpotentialitiesofthemanyinitiativesandapproachesthataredevelopingworldwideinthisfieldwiththefinalaimtomeetworldenergydemand.

简介：Usingmoleculardynamics(MD)methodscombiningwithtwo-stepradiationheatingmodel,themechanismsofablationandthethermodynamicstatesatNisurfaceunderfemtosecondlaserirradiationareinvestigated.Simulationresultsshowthatthemainmechanismsofablationareevaporationandtensilestressesgeneratedinsidethetarget.Thevelocityofstresswaveispredictedtobenearlyequaltosoundvelocity.Theratesofablationatdifferentfluencesobtainedfromsimulationsareingoodagreementwithexperimentaldata.Superheatingphenomenonisalsodiscovered.

简介：MolecularmechanismsoftheKru?ppel-likefamilyoftranscriptionfactors(KLFs)havebeenstudiedmoreinproliferatingcellsthaninpost-mitoticcellssuchasneurons.WerecentlyfoundthatKLFsregulateintrinsicaxongrowthabilityincentralnervoussystem(CNS)neuronsincludingretinalganglioncells,andhippocampalandcorticalneurons.Withatleast15of17KLFfamilymembersexpressedinneuronsandatleast5structurallyuniquesubfamilies,itisimportanttodeterminehowthiscomplexfamilyfunctionsinneuronstoregulatetheintricategeneticprogramsofaxongrowthandregeneration.BycharacterizingthemolecularmechanismsoftheKLFfamilyinthenervoussystem,includingbindingpartnersandgenetargets,andcomparingthemtodefinedmechanismsdefinedoutsidethenervoussystem,wemaybetterunderstandhowKLFsregulateneuritegrowthandaxonregeneration.

简介：AbstractA pancreatic cystic neoplasm (PCN) is a rare pancreatic disease. Malignant PCNs are usually identified incidentally while evaluating other lesions. However, PCNs are being identified more frequently owing to the increased use of abdominal imaging. Malignant PCNs have complicated and diverse biological behaviors, including various malignant risk factors, diverse molecular features, natural history, and complex pathological classifications. Although many diagnostic methods, such as cross-sectional imaging and endoscopic evaluation, have been developed, malignant PCNs are still difficult to differentiate from benign tumors. On searching for related articles in the recent decade, we found that some molecular biomarkers such as carcinoembryonic antigen could be useful for discriminating between malignant tumors and benign tumors. However, cytopathologic evaluation is the most useful method for differentiating between benign and malignant lesions. Although cytopathologic evaluation has a specificity of 100% for identifying malignancies, its accuracy is often hampered by the low cellularity of PCN cells in the cystic fluid. Herein, we review the progress in the use of cellular and molecular markers for the accurate identification of PCNs.

简介：我们学习分子的氧的绑定到一(5，0)单身者原文如此围了nanotube，借助于密度功能的计算。在SiCNT表面上的地点的硅和碳原子的等边六角形的中心是为O2分子的最稳定的吸附地点，与一个有约束力的精力?38.22eV和1.698的平均SiO有约束力的距离?。我们也与abinitio测试了O2adsorbedSiCNT/CNT的稳定性在房间温度被执行了的分子的动力学模拟。而且，单个围的碳nanotubes上的O2的吸附被调查了。我们的第一原则的计算预言硅碳化物nanotubes的O2吸附的能力比碳nanotubes的好一些。这可能为煤气的察觉和精力存储有潜力。

简介：对木头开发和形成的分子的生物研究是相关基因的发现的最近的年，而是步里的焦点，他们在木头性质的控制的函数是慢的。它在另外的工具上的高产量能力，敏感，和可靠性的优点为调查能够的基因表示patternsis开发了的microarraytechniquewith很快assaying几千基因。在这研究，从开发白杨木部纸巾的二个cDNA图书馆准备的cDNAmicroarray从Populusdeltoides的主要的茎在不同高度在不成熟的木部纸巾习惯于试金基因表示模式(15?岁)，它被证实有不同木头性质(microfibrillar角度，木质的密度)旁边X光检查。有在薄片之间的微分表示侧面的274个抄本外面被屏蔽，并且单个克隆受到5定序。用生物信息的分析，我们识别了可以影响白杨木头性质的候选人基因，许多哪个属于各种各样规章并且信号transduction基因家庭例如锌手指蛋白质抄写因素，DNA有约束力的抄写因素，乙烯反应因素等等。结果建议这些基因可以调整涉及木头形成的酶。进一步的工作将被执行克隆这些基因并且决定他们怎么影响白杨木头性质。

简介：这篇散文在软事工程为分子的设计在一条合理、模块化的途径的发展讨论一些初步的想法并且为先进功能的材料建议结构、功能的synthons的想法。它回应由练习的材料染色体行动一试验制动火箭功能的分析RFA计划。在把分子的功能变成并且放大宏观的性质的层次结构的重要性被认出并且强调。根据在最后的材料的分子的片断的角色，有积木的二种类型：结构的synthon和功能的synthon。为需要的功能由特定的结构指导了，这些synthons能模块化地以构造分子的脚手架的各种各样的方法被联合。详细分子的结构然后精确并且模块化地被推出，设计并且综合。当装配结构和性质可以从原来的设计背离时，学习可以向目标功能允许分子的设计的进一步的精炼。策略在软fullerene材料和另外的巨大的分子的发展被使用了。有一些方面，很好还没被探讨：1功能和结构不是充分decoupled并且2装配层次结构越过不同长度规模对第二等的相互作用和分子的几何学敏感。不过，RFA途径由从化学和物理与考虑挑起创造性提供一个起点和一条其他的想小径。这为与超分子的格子形成设计软事是特别地有用的，作为在巨大的分子，在synthons相对独立于对方的地方。

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