简介：HDAC和帽子是哪个的二种酶catalysedeacetylation和在优核质的histone的acetylation，其动态平衡在DNA为基因抄写和优核质的基因表示有精确规定水平。他们的Disbalance能在正常房间带增长和区别的混乱，然后导致肿瘤的开始。他们的异常功能是直接与各种各样的肿瘤的开始和前进有关例如promyelocytic白血病，Hodgkin淋巴瘤，结肠的癌症和gastral癌症。HDAC的禁止者被用于肿瘤的治疗。他们能制止HDAC的活动并且堵住deacetylation的混乱引起的基因表示的抑制。它的主要生物效果在导致肿瘤房间的区别躺着，逮捕在G0/G1的房间圆，激活房间apoptosis基因，提高化学治疗和放射性的治疗的敏感。到目前为止HDAC是在anticancer药research.Cellular与分子的免疫学的重要目标酶。2006；3(4):285-290。

简介：

简介：AbstractCell death occurs in various tissues and organs in the body. It is a physiological or pathological process that has different effects. It is of great significance in maintaining the morphological function of cells and clearing abnormal cells. Pyroptosis, apoptosis, and necrosis are all modes of cell death that have been studied extensively by many experts and scholars, including studies on their effects on the liver, kidney, the heart, other organs, and even the whole body. The heart, as the most important organ of the body, should be a particular focus. This review summarizes the mechanisms underlying the various cell death modes and the relationship between the various mechanisms and heart diseases. The current research status for heart therapy is discussed from the perspective of pathogenesis.

简介：

简介：Toexploretheprevalenceoftheplasmid-mediatedquinoloneresistancegeneqnrAinGram-negativebacteriaandtoinvestigateitsmoleculargeneticbackgroundandresistanceprofileinisolatesharboringthisgene,atotalof629nalidixicacid-resistantisolatesofnon-repetitiveGram-negativebac-teriawerecollectedfromclinicalspecimensbetweenApril2004andApril2006andtheseisolateswerescreenedforqnrAgenebyPCRusingspecificprimerscombinedwithDNAsequencing.Theextendedspectrumβ-lactamase(ESBL)orAmpC-producingisolatesweredistinguishedbythephenotypicconfir-matorytestcombinedwithDNAsequencing,andtheantibioticssusceptibilitytestforqnrA-positiveiso-lateswascarriedoutbyKirby-BauerandE-testmethod.TodetectthelocationoftheqnrAgene,plas-midconjugationandSouthernhybridizationwereperformedandtheintegronstructurecontainingtheqnrAgenewasclonedbyPCRstrategyandsequencedbyprimerwalking.ItwasdemonstratedthattheincidenceoftheqnrA-positivestrainsinnalidixicacid-resistantbacteriawas1.9%(12/629),inwhichthedetectionratesforKlebiesiellapneumoniae.Enterobactercloacae,Enterobacteraerogenes,CitrobacterfreundiiandSalmonellachoeraesuiswere2.2%(3/138),17.1%(6/35),9.1%(1/11),12.5%(1/8),and14.3%(1/7),respectively.TheqnrAgenewasfoundtobeembeddedinthecomplexsu/1-typeintegronlocatedonplasmidswithvariedsize(80-180kb).Amongthem,4qnrA-positiveisolatescarriedintegronIn37and8isolatescarriedanovelintegron,temporarilydesig-natedasInX.AlltheqnrA-positiveisolateswereESBL-producingandtransferableforthemuhi-drugresistance.Itisconcludedthattheplasmid-mediateddrug-resistancemechanismexistsinthequinoloneresistantstrainsofisolatesfromhospitalsinGuangdongarea,buttheincidencewasratherlow.Never-theless,itisstillpossiblethatthehorizontaltransferoftheresistantqnrAgenemightleadtothespreadingofdrug-resistance.

简介：在这篇论文，起诉分发，化学契约顺序和羧基的酸的反应表演，酸的催化剂上的模型混合物被使用分子的模拟技术调查。模拟结果比C-C，和C-C，契约在有的carboxyl激进分子与碳原子连接了，证明公司的契约顺序高。模型naphthenic酸的费用分布在负电荷是的特征是类似的专注于carboxyls.According到模拟结果，在酸的稳固的催化剂上的催化去碳酸基的机制被建议，并且一条新线路关于从通过催化去碳酸基的原油的naphthenic酸的移动被提出。

简介：

简介：

简介：

简介：

简介：INTRODUCTIONMolecularbiologyhasmadeatremendousimpactonthediagnosisandtreatmentofliverdiseases.Inparticular,advancesinmolecularbiologymadepossiblethediscovery

简介：MolecularPlantBreeding(online,ISSN1923-8266)isanopenaccessandpeerreviewedjournal.Itpublishesoriginalresearchpapersinvolvinginthetransgenicbreedingandmarkerassistedbreedinginplants,particularintheareasoftransgene,moleculargenetics,cropQTLanalysis,germplasmgeneticdiversity,andadvancedbreedingtechnologies.Theprimarycriteriaforpublicationaretheinterestingsthatneednotonlytomeet

简介：Molecularmaterialsarethoseconstitutedbyweakintermolecularinteractions(e.g.,interac-tion,hydrogenbonding,andvanderWaalsforce)betweenindividualcomponentmolecules.Whileconventionalsemiconductingmaterialsareconstitutedbystrongintermolecularinteractions(e.g.,covalentbonding,metallicbonding,and

简介：Animportantfunctioningmechanismofbiologicalmacromoleculesisthetransitionbetweendifferentconformedstatesduetothermalfluctuation.Inthepresentpaper,abiologicalmacromoleculeismodeledastwostrandswithsidechainsfacingeachother,anditsstochasticdynamicsincludingthestatisticsofstationarymotionandthestatisticsofconformationaltransitionisstudiedbyusingthestochasticaveragingmethodforquasiHamiltoniansystems.ThetheoreticalresultsareconfirmedwiththeresultsfromMonteCarlosimulation.

简介：Crystalandphasemorphologiesandstructuresdeterminedbyself-organizationofcrystalline-amorphousdiblockcopolymers,crystallizationofthecrystallizableblocks,andvitrificationoftheamorphousblocksarereviewedthroughasystematicstudyonaseriesofpoly（ethyleneoxide）-b-polystyrene（PEO-b-PS）diblockcopolymers.Onthebaseofcompetitionsamongthesethreeprocesses,molecularandsupramolecularorderinginconfinedenvironmentscanbeinvestigated.Inaconcentration-fluctuation-induceddisordered(DCF)diblockcopolymer,thecompetitionbetweencrystalli-zationofthePEOblocksandvitrificationofthePSblocksismomtoredbytime-resolvedsimultaneoussmallangleX-rayscattering（SAXS）andwideangleX-raydiffraction（WAXD）techniques.InthecaseofTc

简介：TreeGeneticsandMolecularBreeding(ISSN1927-5781)isaninternational,openaccess,peerreviewedjournal,committedtoservefortreegeneticsandmolecularbreeding,particularlypublishinginnovativeresearchfindingsinthebasicandappliedfieldsoftreemoleculargeneticsandnoveltechniquesforcrop/fruit/forest/ornamental/

简介：Epithelialovariancancerrepresentsthemostlethalgynecologicalmalignancyinthedevelopedworld,andcanbedividedintofivemainhistologicalsubtypes:highgradeserous,endometrioid,clearcell,mucinousandlowgradeserous.Thesesubtypesrepresentdistinctdiseaseentities,bothclinicallyandatthemolecularlevel.Molecularanalysishasrevealedsignificantgeneticheterogeneityinovariancancer,particularlywithinthehighgradeseroussubtype.Assuch,thissubtypehasbeenthefocusofmuchresearchefforttodate,revealingmolecularsubgroupsatboththegenomicandtranscriptomiclevelthathaveclinicalimplications.However,stratificationofovariancancerpatientsbasedontheunderlyingbiologyoftheirdiseaseremainsinitsinfancy.Here,wesummarizethemolecularchangesthatcharacterizethefivemainovariancancersubtypes,highlightpotentialopportunitiesfortargetedtherapeuticinterventionandoutlineprioritiesforfutureresearch.

简介：无

简介：提炼伴随转变从的变化对在蝗虫的独居的阶段状态群居是那么激烈的很长时间，这些阶段被看作不同种类。是鲍里斯·乌瓦罗夫介绍了polyphenism的概念。研究的十年表明阶段转变在morphometry，表皮的颜色，行为和生理学的几个方面暗示变化。在最近的十年，特别地，相当很多分子的研究被承担了揭开阶段相关的差别。他们导致了新奇卓见进corazonin的角色，neuroparsins，一些朊酶禁止者，phenylacetonitrile等等。蝗虫的EST数据库的来临(例如坑等，2004)是在生理、行为的蝗虫研究的很令人鼓舞的新奇开发。然而，最吸引人的问题的答案，也就是是否有阶段转变的初发的分子的inducer，在不久的将来可能不在活动范围以内。

简介：Theuseofmolecularbiologyandgenomicstoolsinplantbiologyresearchhasgreatlyexpandedourunderstandingofthemolecularmechanismsthatunderlieplantdevelopmentandphysiology.Thesuccessfulestablishmentofresearchresourcessuchasmutantpopulationshasledtoprogressinavarietyoffields,includingplantreproductivedevelop-ment,signaltransduction,hormonefunctions,defenseresponsesandepigeneticcontrol.Inthefuturetheseadvanceswillpotentiallyfacilitatecropimprovementthroughmolecularbreeding.